Chapter 2 Tamoxifen Goes Forward Alone
نویسنده
چکیده
Tamoxifen (ICI 46,474), the trans isomer of a substituted triphenylethylene, was discovered in the fertility program at Imperial Chemical Industries, Pharmaceuticals Division, Cheshire, England. The plan was to use tamoxifen to regulate fertility, but this failed and interest refocused outside the company for applications to treat breast cancer. The initial application of the nonsteroidal antiestrogen was for the treatment of metastatic breast cancer in postmenopausal women and by the 1980s tamoxifen had replaced high-dose diethylstilbestrol therapy. Efficacy when compared with diethylstilbestrol was similar, but tamoxifen had fewer side effects. No other antiestrogenswere developed by the pharmaceutical industry, as this was not considered a financially lucrative development strategy.
منابع مشابه
P-195: Thymoquinone Increases Efficacy of Tamoxifen Induced Apoptosis in Human Breast Cancer MCF-7 Cells: In Vitro
Background: The objective of this study is to evaluate combined effect of Thymoquinone (The main active component of black seeds) with Tamoxifen drug on apoptosis of human breast cancer MCF-7 cells (Noninvasive human breast cancer cell line, estrogen receptor positive). Materials and Methods: The human breast cancer MCF- 7 cells were treated with Tamoxifen (2 μM) alone or in combination with Th...
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Tamoxifen is routinely used for treatment of Estrogen-positive breast carcinoma. Approximately, 50% of patients with metastatic cancer will develop resistance to Tamoxifen. In this research, Tamoxifen was combined with the anti-cancer compound Curcumin. Diblock nanopolymer was used to package the new formulation of Curcumin and Tamoxifen. Anti-cancer efficacy of the obtained compound was evalua...
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It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...
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